WP3 Incorporation of antimicrobial agents into polymeric structures

Leader of consortium:

SYNPO, akciová společnost

Consortium members:

Centrum organické chemie s.r.o., Fatra, a.s., INOTEX spol. s r.o., Univerzita Palackého v Olomouci, Univerzita Tomáše Bati ve Zlíně

Responsible person:

Ing. Jiří Horálek, CSc.

Duration of the work package:

01/2014 – 12/2018


Aim of this work package is the suggestion and design of suitable materials able to bond covalently into the carrying polymeric structure.
Suggestion of an effective way of synthesis will transfer their preparation into glass pilot plant addressed by WP9. This work package is divided
into four fundamental tasks, which are supposed to cover all aspects of the material synthesis required by the targeted applications.

Task 3.1, Preparation of polymers with reactive bonded commercially available antimicrobial agents, synthesis and optimisation of the structure of polymeric carriers.

The first route to the synthesis of antimicrobial polymer is the synthesis of nonnumeric antimicrobial substances based on organic compounds
containing reactive functional groups suitable for their incorporation into the structure of polymeric chain during the synthesis of polymer. These
functional groups will be hydroxyls and amines including their combinations and namely polymerizable C=C bonds. These polymers will be used
as binders or additives in coatings. The commercial available antimicrobial agents or confirmed biocidic structure will be used for starting work.
There will be choice such types of molecules, where will not any contradiction with valid laws.

The second route to the synthesis of antimicrobial polymer is the preparation of suitable carrying polymeric skeletons containing reactive
functional groups, namely carboxyls, sulfonic groups, amino groups, anhydrides or isocyanates. These reactive polymeric carriers will be utilized
to the chemical anchoring of low molecular antimicrobial substances by ionic or covalent bond. This way, so called derivatization, will be used for
the case that the route listed above in the Task 3.1cannot be used. The example of such case is antimicrobial monomeric substance having in
the structure aromatic hydroxyl and having character of polymer inhibitor. Polyacrylates, polyesters and polyurethanes will be synthesized and
used first of all as polymer carriers, in special case will also be applied hybrids, e.g. acrylurethanes, capable to be chemically bonded to textile
fibre. Chosen systems will be proposed to the testing as conservants in cosmetics.

Task 3.2, R&D of polymeric structure suitable for bonding of phthalocyanine, proposal and synthesis of polymers with the phthalocyanine photosesitizers

Alternating copolymers will be synthesized to the anchoring of photoactive phtalocyanines-photosenzitizers in polymer matrix by ionic bond.
Random copolymers cannot be used in this case from the sterical reasons (voluminosity of phtalocyanine molecule). Hydroxyls, primary or
secondary amines in the structure of phtalocyanine compound and isocyanates or anhydrides in the structure of polymer matrix will be utilized
as reactive groups. These antimicrobial polymers will be suggested for surface modification, where the suitable source of light can activate their
antimicrobial effect.

Task 3.3, Suggestion of polymeric system as carrier for silver nanoparticle.

Synthesis of polymeric carrying structure, suitable for link up antimicrobial substances inclusive of reactive Ag compounds (Ag in active form is supposed to be a part of polymer matrix) will be proposed and
optimised. Suitable antimicrobial polymers able to be fixed on textile fibre will be formulated.

Task 3.4, Proposal, optimisation and synthesis of antimicrobial polymeric masterbatches

Chosen antimicrobial polymers will be crosslinked into the insoluble three-dimensional polymeric structures. These systems, marked as
masterbatches, will be utilized in thermoplastic or reactoplastic coatings. Compounds containing on the one hand Zn 2+, Cr 3+ , Zr 4+ , Ti 4+ ,
Si 4+, on the other hand polyfunctional alcohols, amines containing acidic hydrogen atoms, aminoalcohols and their combinations will be used
for the preparation of antimicrobial masterbatches.Structure of these masterbatches will be optimized and tailored to final application using.
Masterbatches will be used for preparation of foil and surface modification of thermoplastic products.

Project no. TE02000006 is solved with financial support
from the Technology Agency of the CR.